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Native IGF-1 binds IGFBP-3, the dominant carrier protein in circulation, with a dissociation constant in the low nanomolar range (Kd approximately 0.1 to 1 nM in most published binding assays)

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Another study investigating the effects of 4-HNE on cardiomyocyte DNA repair capacity reported that the activity of 8-oxoguanine DNA glycosylase 1 (OGG1), a key enzyme responsible for repairing oxidative DNA damage, was significantly reduced in the myocardium of db/db mice, accompanied by elevated 4-HNE adduct levels