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Silent information regulator 1 (SIRT1), an NAD + -dependent deacetylase, has emerged as a central regulator at the interface of metabolic regulation, inflammatory signaling, and cellular defense mechanisms

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While a similar impact of HODEs on adipose FABP4 expression has not been demonstrated, this protein is strongly associated with the development of insulin resistance and atherosclerosis 694 and research in this area is warranted